Social isolation is a huge issue for me. When I spend multiple consecutive days working from home I start to get mildly depressed. Going out at night after a day of working from home doesn't fix it. I think it has to do with what I'm used to from nearly two decades of schooling: socializing with and being in the company of many other people during the daylight hours of weekdays.

Lack of face time can be a problem when it comes time for advancements. If you work for a company that is purely remote and software driven, this might not sound like a big deal, but if you work for a company that is: a) not 100% remote and b) not a pure software development company, the office crowd and non-tech higher ups start to wonder: a) who you are and b) what you do there.

Good thing this boat seats two.

Not really taken advantage of in my case, but it can sometimes feel like you need to "prove yourself" that little bit extra (maybe the guilt of not being seen?) and end up working longer due to that

>lack of networking

Not when I worked at home. When I was working at home, I could get done with work exactly at 5 and head over to the weekly meetings of local organizations (ACM, local LUG, the hackerspace in town, 2600 meetings sometimes) and network there much more than I could if I had to drive out to where they were from my office.