ClamAV [http://www.clamav.net] is my aid, I use it on macOS and OpenBSD.
- https://raw.githubusercontent.com/Homebrew/homebrew-core/mas...
- http://cvsweb.openbsd.org/cgi-bin/cvsweb/ports/security/clam...
It's unobtrusive, and I can fully control its behaviour (under usual circumstances a simple `freshclam && clamscan -i -r $PATH` is enough).