On the other hand, observations about Lorentz symmetry holding at distances on the order of the Planck scale put a wrench in a bunch of discrete spacetime theories. I don't really understand the math, though.
All this is somewhat tangential to the issue of real numbers. Real numbers are not necessary for continuity.
Some of them extremely useful :)
You know of any continuum that doesn't include the real numbers? That will contradict the continuum hypothesis.
This happens fairly often in mathematics, where similar-sounding terms are used to describe completely different concepts, or the same term sometimes means different things in context, or sometimes an Adjective Noun is neither described by Adjective nor by Noun.
QM (and QFT) assume a background time, it is not an observable, even though it appears to commute with energy (e.g. energy is momentum in the time direction). So it's more tricky to understand how time emerges in a discrete Quantum Gravity, but I suspect there is an intrinsic proper time, defined by interactions with the 'vacuum' (minimal field states on the underlying lattice), which bootstraps a relational time defined over intervals between interactions.
If true, then we can think of the continuity just as a convenient interface. All experimental questions can be answered by a simulation with a discrete state space.
(That is, presuming that you're speaking of the particle physics Standard Model, not something in cosmology.)
That's not really ELI5, but remember learning derivatives in calculus? Just like you can't take the derivative of a function which isn't continuous, you can't use the Standard Model if spacetime isn't continuous.
1. What does it mean to be "discrete on a macroscopic level"? (If a universe were discrete, would it not be discrete at any scale? When we use the term "discrete", are we talking about state space, or discrete spacetime, or what?)
2. What does it mean for a universe to "inherently [be] a natural number"? (Universes are not numbers, right? Is some sort of claim that the universe's state space is finite?)
3. What does have to do with whether a universe was "intelligently created"? (How can it possibly make sense that "intelligent creation" is an alternative to a discrete universe? The claims seem entirely unrelated.)
The "explanation" comment doesn't attempt to explain anything so I'm not sure why you call it an explanation. (Well, perhaps it explains that a conditional with a false antecedent is logically true, but most people here already know that, so pointing it out is not a great way to contribute to the discussion.)