Some software already removes complete silences, but this is a 10% effect and I think this could be taken much further. I would love audio software that could manipulate high-speed human speech to improve intelligibility by preferentially compressing parts with low information content (like vowels and "ughs") and uncompressing, or even "repairing", info-dense parts like sequential consonant sounds.
I've looked around and haven't been able to find anything like this. Could make a nice stand-alone app, or a library to sell to a podcast player.
http://softwarerecs.stackexchange.com/questions/27175/video-...