For my eyes, the f.lux nighttime adjustment and configurability is great. at work, i use it during daytime hours as well, helps greatly with eye strain.
Night Shift is like an introduction of the concept to a mass audience, surely it has a positive benefit for the uninitiated but there's a lot missing for folks who rely on it. Android is much better with multiple applications available to control this.
I thought it would have been a good gesture for apple to buy f.lux and get the "market leader", and some built in goodwill, as opposed to just copying them, but I guess such is life when you are the largest corporation in the world.