it seems this would be a great use case for DAWs and sample libraries in general, many many small files to be accessed with extremely low latency: this could make it possible to run large orchestral templates fully purged at all times, which would be a great use case when your template has hundreds of GB of samples but you only use a few of them at a time.

This is already kind of doable with SSD, but if optane has an order of magnitude less access time it would of course make it even better for this use case.