Care to amplify that comment a bit for those of us in the cheap seats?
Wikipedia has quite a bit of information about p53. [1] It seems to have an important role as a suppressor for cancer. So maybe the comment was referring to that, you probably don't want to mess that up.
When apoptosis fails, it's might be because p53 binds to foxo4 and gets stuck in the nucleus which prevents the p53 from getting to the mitochondria. In the experiment p53 in the paper, p53 unbound from foxo4 in the nuclease and bound to foxo4-dri and successfully flowed down the mitochondria so apoptosis could occur.