1Password, and it's been awesome. If you use the non-hosted version you control the whole thing. LAN only sync, or Dropbox, Rsync, however you want to sync it if it matters. Otherwise they've got a hosted version which can also give you web access in a pinch and handle all the syncing for you. I have been with them for long enough that my only option was a non-hosted version and I keep in sync with Dropbox and it works wonderfully.

The Mac client is very nice to use. The Windows client works well but isn't as nice looking. The browser extension is awesome- AND you can put MFA keys in there as well.

EDIT: And I forgot to mention the main reason I chose 1Password so long ago. Their iOS app is awesome and their mobile Safari integration works quite well.