There's an entire universe (metaphorically, if not literally) of unusual experiences which are routinely dismissed by materialists because they "know" they can't possibly happen, and therefore it's completely self-evident that anyone who claims they do happen is either deluded or dishonest.
Therefore no evidence exists, and no investigation is required.
This is not actually a scientific approach to reality at all. It may be economically expedient - resources are limited, after all - but let's not confuse tribal scientific tradition with absolute empirical certainty.
It's even less scientific to assume that the physics of the world in which we might be being modelled is identical to the physics of this reality. That make as much sense as claiming that we can't possibly live in a modelled world because of Lorentz invariance.
I don't think we can even be sure that the math and logic of a possible super-reality is identical to this one. You can't have a universe without rules, and where did the rules for this universe come from? It's a deeper and more interesting question than wondering where energy, matter, and spacetime came from, because it implies that either math exists in some kind of magical eternal Platonic way, or there are processes we don't know about which somehow generate math and logic - before things get real.
The point being that speculation and research are far from useless, either scientifically or philosophically.