Show HN: File System Performance Testing Tool for Windows
ccsiobench.com
ccsiobench.com
The theory is over at https://ccsiobench.com/fast-bulk-io
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NVMe drive from my test box - https://ccsiobench.com/s/UAr3fSSD in USB3 enclosure - https://ccsiobench.com/s/UAtNj
TrueCrypt volume on the same - https://ccsiobench.com/s/UAxmh
For two, you can estimate the overhead you get by enabling NTFS compression and/or Bitlocker for a drive.
Ditto for the antivirus overhead. For example, BitDefender is known to absolutely kill multi-stream SMB3 performance, dragging 10GbE speeds down to 1Gbps or less.