I used to live on the north east side of Edinburgh and commute by bicycle to a location on the south west side of the city (Riccarton campus) - this was great as it was up hill and into the prevailing wind in the morning and down hill and wind behind you at night.
Nice reasoning. (Though only applicable to 'newer' cities, or at least more recent expansion of cities).
Also only to people that commute at rush hour +/- and into/out of the city.
Which for smaller cities is most people
Assuming you drive in a western direction to get to work, sure.