At Lucid Software we use the Closure Compiler with advanced optimizations to build both Lucidchart and Lucidpress. You can see some work we did with it in respect to Angular here: https://www.lucidchart.com/techblog/2016/09/26/improving-ang...

I don't have a direct comparison to Uglify, but as of last fall advanced optimizations does save us about 2.5 MB over simple optimizations.

We're also using Tsickle (https://github.com/angular/tsickle) and Clutz (https://github.com/angular/clutz) to be able to use TypeScript with our Closure Compiler compatible codebase. Closure Code can be depended upon in TypeScript code and vice versa. It's been awesome to use the type system of TypeScript in combination with the minification power of the Closure Compiler. The build process is definitely a bit crazy at the moment, though.

Disclaimer: I work at Lucid Software.