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Looks like the main SNP in consideration is: https://www.snpedia.com/index.php/Rs1990622. Anyone see the particular allele value that increases risk? My guess (looking at some genetic family data) is if you having an "A" instead of a "G" is the mutation - can anyone confirm?

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The mutations found are in the protein TDP-43 [1]. This protein is also involved in ALS. It appears to be a regulatory DNA-binding protein. The protein also helps splice the mRNA of CFTR - the cystic fibrosis transmembrane conductance regulator.

[1] http://www.uniprot.org/uniprot/Q13148

Looks like that's it: "We identified 2 coding variants: one rare variant which was observed in a single control (c.401G>A; p.S134N) and one common variant (rs3173615, pT185S)." (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034409/)

Heads-up: 23andme data contains this gene:

cmbpr:raw_23andme caleb$ grep rs1990622 *.txt

genome_Person1.txt:rs1990622 7 12283787 GG

genome_Person2.txt:rs1990622 7 12283787 GG

genome_Person3.txt:rs1990622 7 12283787 AG

I have 'A or G'

https://itsosticky.com/1qz58aj

Any idea what this means?

I hope someone who understands the article can offer an explanation about whether it's possible to use the 23andme data to speculate about one's own susceptibility to this.

Seconded.

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