Yes. Each frame can specify a region of the overall image, usually just the bounding box of the changed pixels. There are a few options for retention:

    APNG_DISPOSE_OP_NONE: no disposal is done on this frame before rendering the next; the contents of the output buffer are left as is.
    APNG_DISPOSE_OP_BACKGROUND: the frame's region of the output buffer is to be cleared to fully transparent black before rendering the next frame.
    APNG_DISPOSE_OP_PREVIOUS: the frame's region of the output buffer is to be reverted to the previous contents before rendering the next frame.

Supported http://littlesvr.ca/apng/inter-frame.html