I don't see that as a problem, really.

Well behaving sites end up on your whitelist. Everything else gets tossed into the "yet another bloated crap page" bucket.

I do that. One discovers that some sites include a dozen of third party js. Often enabling the first party one is enough. Sometimes I have to enable some obvious js for displaying videos or comments. Many sites work well enough and display their content without all the related links, advertising, trackers etc. Some sites insist using js to display content that is already inside the main html file. Others break because their main script cannot handle the failure to load some other file. That used to happen when blocking Google analytics. The popularity of adblockers fixed that.

All considered it's an interesting developer experience and the sites I work on keep working even if some scripts don't load.

Seriously, I'm been using it for more than 5 years and I've only enabled it for local sites and everything is working.

It depends on what sites you browse. I don't do any social, use google or any other crap, so it's enabled to 0 internet sites with no problem.

If I need to activate it I have a shortkey (vimperator) that opens a new firefox profile (private and prepared to load crap) for the current site so I don't load any terrible UX in my default profile.

NoScript, ublock and SDC are a must for the current state of Internet. It's like drop the garbage out the window than in the garbage bin, you need to put care into it. :)