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I wouldn't say "must", but Photoshop is absolutely the best thing on the market for image editing.

What's your workflow for creating, say, sprites, if you're not using Photoshop?

> What's your workflow for creating, say, sprites, if you're not using Photoshop?

"Hey [designer name], can you export a sprite-sheet for [app name]?

Why would a developer be creating sprites? A designer would do that, normally.

Exactly.