Trello is actually slow, because of that backend stack, I imagine. I thought the author was going to point to that.
It works fine for other boards, so I assume it wasn't built with so many lists+cards in mind. But the fact it, it can be slow, almost unusable, at least for certain use cases.
[1]: https://blog.fogcreek.com/we-spent-a-week-making-trello-boar...
From a user experience perspective it is freaky fast at updating other clients.