To me, HI seems more like a discussion between two friends. It works really well because of Brady's reporting background and interviewing skills. In Cortex, however, Myke has said that he started the podcast because he wanted to see how Grey worked. As such, the podcast is just kind of a continuous explanation by Grey, to Myke about the way he works and what he is doing to improve his productivity. Myke then explains what he is doing off of Grey's advice and Grey improves it.

Sometimes I get really annoyed with it, as it can be three guys complaining about Apple in general, which I don't care too much about.

The real good stuff comes when they talk about programming, gaming, and cars, which happens every episode. They also had a good interview recently with Chris Lattner that is worth the listen.