I could def see being shoeless helping things out. However, by definition most of these VR systems are wired into a computer on or near desk. I could easily see someone tangle and then trip over the wire and then hit their head on the desk.
In fact, just google "VR Injuries" and you'll see way more examples then say happened with the nintendo wii, pre strap, a change they made because they concluded without it the wii was too dangerous and lawsuit prone. The original wii has nothing on current state VR. If it became any where near as widespread as the wii did with it's current implementation, there would certainly be a few more entries to the Darwin awards...