For example, statistical causal models are widely used in the social sciences. After searching within the field, I looked for a problem associated with explanation ambiguity due to how the models were framed (or could be equivalently framed leading to alternate explanations) and found this paper:
MacCallum, R. C., Wegener, D. T., Uchino, B. N., & Fabrigar, L. R. (1993). The problem of equivalent models in applications of covariance structure analysis. Psychological Bulletin, 114(1), 185-199. doi:10.1037/0033-2909.114.1.185
I'm not sure if they could extend their approach using manifold theory and an equivalence class for the set of models, but I wouldn't be surprised if someone did something similar. It could then be an example of a coordinate-free approach to data analysis in psychology.