My main complaints are - 1) The updates for GPS versions have been quite bad recently. 2) Can't run VirtualBox and Haxm on the same machine.
That's exactly what I do. Didn't try it on the same time, though.
What I had problem with in the past, was running Hyper-V and HAXM. Both require their own hypervisor, both need a reboot to activate it and they cannot be active at the same time.