Association between polygenic risk scores for ADHD and cognitive outcomes

Also, the thing you've observed in your friends is similar to something I've observed in myself (this can be pretty fraught, so big grain of salt). I tend to see patterns or connections between lots of little bits of seemingly unrelated data where others don't. I'm not sure if this is because I'm better at discerning patterns, or if it's because I tend to collect and store all these little odds and ends more than others normally do. It's also possibly a 'involuntarily trained' skill: quite a bit of the time I find myself scrambling to deduce what is going on based on contextual clues, because I'd been daydreaming and all of a sudden I find someone asking me "so what's you opinion?"

Frankly it's more of a curse than anything. I sometimes feel as if I'm pleading with someone to "step off the train tracks" because I can see a train bearing down on them, and they adamantly refuse because they see no such thing.

This gets my vote. I've met brilliant ADHD hacker-types, overall average normal folks, and drop-out homeless people. They all did poorly in school but the rest seems up in the air.

I suspect there are several comorbid complementary/incompatible genetic mutations, which lead to above-average or below-average mental faculties, and a nurture component of learning how to effectively manage the condition. We're probably observing evolution in action here.

>What must be discovered is a way out of the motivation/ demotivation binary, so that disidentification from the control program registers as something other than dejected apathy. One strategy would be to shift the political terrain - to move away from the unions' traditional focus on pay and onto forms of discontent specific to post-Fordism. Before we analyse that further, we must consider in more depth what post-Fordism actually is."

Mark Fisher - Capitalist Realism

The challenge in the end, I suppose, is to overcome yourself. Being 10, you're only starting, and things will get better, especially mid-twenties, so you've a good road to walk. Step by step :)

Focus on how you can utilize your mental makeup to shape your life rather than bend others. Reduction of zero-sum dog eat dog thinking would help ameliorate any social aspect of your anxiety. I didn't have much to go off of from your post but I hope that helps.

There are tons and tons and tons of publications that keep on getting published on running similar datasets with the same methods (PCA, regression or MLM, done) and then reporting the associated SNPs. In humans these papers are getting huge with massive datasets, like this one: http://biorxiv.org/content/early/2015/05/27/019885

There was also this interesting paper which relied on a very specific configuration of a human population, you cannot do that with for example Brits: http://biorxiv.org/content/early/2015/11/12/031518

By its very nature GWAS cannot prove a causal relationship, I'm now hoping that CRISPR-Cas9 can provide for that - use GWAS to find candidate SNPs, use CRISPR to introduce those SNPs in an unaffected population, measure phenotype changes. Of course with sequencing getting so cheap you can start with SNP calling and get a much more comprehensive picture by looking at large scale insertions and deletions by just looking at the whole genome, like this paper for 10,000 (!!!) humans: http://biorxiv.org/content/early/2016/07/01/061663

Jargon in academia is definitely overused, but in this case the terminology they're using has specific meanings, that this is meant to communicate to people within the field, that are lost or obscured when you attempt to simplify them.