The murder of Theo van Gogh and subsequent threats against other artists, authors, etc. are terrible acts. No one should be killed for such expression.
But I have to say - I find any "juvenile attempt to troll a religious group," well, juvenile and trollish. It is uncivil and rude. It promotes division and distrust, and actively destroys the work many have put into creating safe atmospheres of expression and mutual respect by ridiculing a religious community.
I am not a Muslim. The closest affiliation I'd claim might be with some liberal emerging christianities. But I believe in respecting others enough not to make fun of deeply-held beliefs, which I myself do not hold and which do not impact my life but are absolutely central to the worldviews and spirituality of a very signification portion of the world's citizens.
I'd suggest that "valuing free speech and reason" needn't involve encouraging socially destructive behavior intent on marginalizing a people group, self-selected or not.
When I first watched the south park episode I was very confused.. then I watched the backlash unfold.
I think this movement is needed to get this out into the open. What would you say if Skin Heads, KKK, or any other racist organization threaten violence and we bowed out.. stopped the presses and let them have their way.
This is what we are doing by tip toeing around the issue in our country, censoring our media, and for what? We need exactly this movement because it is "uncivil and rude".
Nothing promotes more division and distrust like murdering someone for drawing an image or punching someone in the face for it. Yes, if you think about it as "trolling a religious group" it does sound juvenile. But you think about it as an act of solidarity with those who have been killed or punched in the face, then it makes more sense.
Locke was in it for the lulz, no doubt.