We got two spaniels (years apart) from the same breeder. Both died suffering of a number of abnormalities that became pronounced when they got older.
Later we found that the breeder was forced to stop altogether because the dogs were so consistently damned.
I can still hear what I can only describe as "screaming" by our first spaniel the night she came home after an emergency operation. She had to be let go that night. Nothing in my life has haunted me the same way. That was it for dogs for me. I have two wonderful cuddly cats and I'm delighted by how genetically unremarkable they are.