There are two challenges here. One is that MongoDB has a different data model than MySQL: hierarchical, schema-less documents instead of uniformly-typed flat tables. It's possible to map one to the other--look at Postgres' support for JSON datatypes. That involves extensions to both the storage format and query language, but it's certainly doable.

The bigger problem is that MySQL's local transactional isolation is nice, but not particularly helpful in a distributed context. Distributed transactions--even single-document ones--are still tough to implement correctly and efficiently. As an example, consider Percona XtraDB, or MySQL+Galera Cluster. Both are building on a serializable single-node system--but in a distributed context, they wind up failing to provide snapshot isolation, let alone serializability.