MobX makes React simple because it's JavaScript. If you've write React with ClojureScript, you will find out that ClojureScript simplified React too. And people may also say ClojureScript is the magic piece that make React great.
It's a start... because it brings the concept to Javascript, a language that I'm already familiar with and have a build chain for.
If one is going to switch languages, then you can consider the whole sweep of compile-to-JS languages. Elm is pretty nice in that scenario, and pairs well with my use of Elixir on the backend.