> Selenium IDE makes you handle timeouts manually which is a major inconvenience.

you can set the implicit wait setting. this will work in most cases but will make the tests slow when you need to test negative conditions. the behavior around implicit wait varies by driver implementation which can be annoying. in general it's better to use explicit waits.

> Selenium IDE only works with Firefox and may not work for sites or web apps that have slightly different DOM structure in Chrome, Safari, and IE.

selenium ide has webdriver playback[1]. if you don't like that you can generate webdriver scripts in c#, java, python, or ruby and run them against selenium server.

[1] http://blog.reallysimplethoughts.com/2013/02/18/webdriver-pl...