As of 10.12.4 you won't need f.lux as the functionality for night shift is built into macOS.
you should do it then? f.lux is already ratcheting down gamut so you're wasting resources running 10bit color on top of it.
It's like using a color printer to print only black text documents, it doesn't make a whole lot of sense in the efficiency department.
But if I'm using the f.lux color space, I presume I can't change it to a different one without breaking it. I haven't tried it, though, but apparently it's moot with the new OS.