A guitarist friend decided to "test" me once and put this in front of me and ask what it would sound like: http://el34world.com/charts/Schematics/files/randall/Randall...
My immediate response was: "That looks like a really great amp from the mid 1980's--looks like it was designed by someone who actually understands electrical engineering. It should have a pretty clean. But if you overdrive it, the clipping on those JFET's is gonna sound like fscking buzzsaw trash."
He, of course, laughed knowing that Dimebag Darrell used the amp for precisely that buzzsaw sound. You would have to add lots of "clipping" components to get the same sound out of depletion mode MOSFET's.
Now, whether that's a good sound is open to debate. :)