I've testified as an expert witness in patent cases in both the UK and the US. In both cases I was testifying that the patent in question should be invalid, and in both cases we were successful. It's much harder to invalidate a patent, because the burden on proof is on you.
The UK and US systems are very different - in the UK you testify in front of a professional patent judge, and they tend to be fairly technically clueful.
Both cases were very hard work - top patent lawyers are very smart, very well paid, and are experts at finding ways to undermine your credibility.
Where the UK and US differ is in how the lawyers go about trying to undermine credibility. It's much harder in the UK to get away with claiming something without it being supported by careful evidence. At one point in the UK case, the issue came up of whether it was technically feasible to run X windows over a dial-up modem. I said that it could, but it certainly wouldn't be quick. When their lawyer tried to dispute this, the judge chimed in, and said he knew personally that it could, because he'd done it himself years before, and could they move along to their next question please. I had a hard time not laughing.
The lawyer's strategy in the UK seems to be to start from a point the expert agrees with, then take them step by step, each step being reasonably in itself, until the expert ends up contradicting their own evidence. Generally, in the UK, if the other side manages to find an angle on something where you don't have evidence to back up your point, you usually need to concede the point. If you don't you lose credibility with the judge, and then it's all over. To avoid such traps, you need to know the 2000 pages of evidence so well you can jump to a particular page, where there's evidence to back your point up.
In the US, you need to maintain credibility with the jury. That's really quite different, as they're not technical. You've got to look them in the eye, and do your best to explain how it is in minimally technical points. They often won't be listening to the technical issues, but just trying to decide whether you're lying. They'll likely go with whichever expert they decide to trust most. I've never testified on something I didn't believe in, so looking the housewives in the jury in the eye and trying to explain earnestly was not so hard. I think juries are actually quite good at detecting who is being evasive if you talk straight to them, but few technical witnesses feel comfortable giving evidence, and this adds noise to the process.