With this mix of C and Python it's impossible to tell what will happen to the system's performance when you actually include significant amounts of business logic written in Python on top of the C framework here. The author even makes a point about how little actual Python code and/or data structures are in use. If use of the host language is discouraged in the framework, how can I trust the performance of the framework with my code written in the host language?
I bet if you put anything non-trivial on top and try to connect with real-world http clients which mostly don't use pipelining, it will fall over hard. Enjoy debugging what you can't understand.
The emphasis on http parsing using SSE intrinsics is odd, as http parsing is rarely a bottleneck. I'm not saying it can't be, but that'll only be when you've got the rest of your stack highly tuned, performance is predictable, and profiling has shown that http parsing is your actual bottleneck. Even so, http/2 in theory alleviates this bottleneck and you don't have to use processor-specific intrinsics, as well as providing a better solution to pipelining problems with its multiplexing of requests.
EDITED: "how can I trust the performance of the framework with my code written in the host language?" Original text lacked emphasized addition.