Are you a one man team or...? My wife would probably leave me if I was on-call for that long.
But the constant nagging in the back of your head that shit can go wrong at any second is draining and has been the biggest stressor in my life for a long time now.
My S.O. still gets mildly upset when I pack up the laptop on our way out to a fancy dinner, or disappear with my laptop when visiting her parents, but the fact that our life goals are aligned is the saving grace of all these situations. We both know what we want out of the next 5 years of our lives and are willing to sacrifice to achieve this goal (long term financial security).