You can have ad blocking, but you can't have the fast JavaScript engine and ad blocking, unless you are Safari. So you can't have a Chrome or Firefox with both, unless Apple fixes their APIs or allows the "real" versions of those browsers.
What's the technical issue?
Thats only used for user initiated navigation, not loading of assets.
You could still inject a JavaScript file or CSS file though to help hide pieces of the view. But that would be content blocking after the HTTP requests have been made.
I don’t know of a way to intercept the HTTP requests as they’re being made from a WKWebView like Safari does for content blocking.