What is upstream?
Of course the 5k monitor does have three USB3 ports. (Not Thunderbolt ports, ostensibly because there isn't enough bandwidth left.)
[1] https://www.cnet.com/forums/discussions/upstream-vs-downstre...
Essentially only one wire goes to your laptop/pc instead of 3.
Edit: according to this random internet stranger, it works fine: http://www.apple.com/shop/question/answers/product/HKN62LL/A...