I think such things can be discounted by knowing that motorways never have stop signs (same with the prank stop signs). Of course, there are a lot of things that only cause a change in driving behaviour in very specific contexts. The bus' stop sign probably only applies when the bus is stopped. Similarly, in Germany at least a bus may turn on hazard lights on a bus stop, requiring everyone to drive past only at walking speed. A bus stopped on the shoulder of a motorway with hazard lights on is a different context again and thus should not trigger the same behaviour.
There are a lot of rules and laws and they change from country to country, or in the US' case, even from state to state. Self-driving cars must know these things and react accordingly. So I think the scenarios presented here are just a few (admittedly, more far-fetched than others) more contexts amidst the probably hundreds of others that already have to work correctly for switching safely between city and motorway driving, driving in a living street, observing right of way correctly in all circumstances (roundabouts, weird stuff like four-way stops, signs changing ROW for one intersection, or a stretch of road, lowered kerbs, people exiting a living street even though it's to the right, cars on an on-ramp and perhaps letting them in based on how far the on-ramp still continues, ...).
Stop signs are interesting in any case, since they have a characteristic shape. If we go full autonomous, then snow-covered signs must be correctly observed as well, at which point any octagon shape may be a stop sign (perhaps, again, depending on context). Same with signs that don't reflect well anymore at night.