Well, rust-belt protectionism played a key part (NAFTA, TPP). I was a Bernie supporter and was really disappointed when Hillary didn't co-op Trump's working-class rhetoric or get energized to at least compete in that battlefield. This is what Bill excels at. Obviously she shut him out of the core team.

Also, she was not that compelling as a candidate. And had all those negatives that I won't go into. Most of them false. But still, why do you put up a establishment candidate on a change cycle (looking at you Wassermann and Brazille, core dems)?

Edit: I don't especially like TPP but I saw it as a strategic shift to Asia for the US. Now China will likely join a TPP-light and really benefit. For better or worse this is going to be a big change over the next 20 years.