The quest to create animals with human organs

There are several competing lines of technology:

1) humanized organs in animals such as pigs.

2) decellularization of animal organs, such as from pigs, followed by replacement with the patient's cells.

3) outright creation of organs from scratch, from a patient's cells (e.g. https://www.neworgan.org )

4) repair of existing organs in situ.

It will be interesting to see how it shakes out; #1 and #2 are only in the running instead of #3 because no-one yet has a good solution for creating the blood vessel networks needed for full size tissue engineering. At the moment only organoids or other thin tissues (e.g. trachea, esophageal lining) can be constructed reliably. #3 is only a goal to the extent that #4 isn't figured out: how to spur regeneration and change cell behavior for the tissues that exist.

Isnt this counter productive to the antibiotic resistance increase ? Alot of animals are given antibiotics, if they had actual human organs wouldnt that make things like swine flu more common and bacterial outbreaks worse?

I'm constantly amazed by the complete lack of ethics in a lot of scientific research. I do admit we all benefit from it, but actually using sentient beings as organ-farms is so far from morally acceptable, I'm amazed how people are still willing to work on something like this.