Even with stock Android, on devices != Pixel or Nexus, Google parts are sandboxed in a way making it hard for them to access private app data. The only way would be to deliver a different app through play store which is easy to discover as it breaks the cryptographic signature and must be done on first install (android uses TOFU).

So without the mentioned issues through Play Services and Gboard, Google would not be able to access your Signal messages. On Stock Nexus/Pixel builds they can of course push updates that change this...