Pretty solid program to get started running.
After that, I'd suggest doing Bridge to 10K [1]
Surprisingly to me at the time, Bridge to 10K was way easier than C25k
BUT increase your speed very carefully, or you will hurt your knees possibly giving yourself a semi-permanent (recurring) injury or worse. Beyond a certain point injury rates shoot up with speed a lot more than any health benefits do, more so than with distance as it is easy to let your form slip when concentrating on speed, and in my experience the only advantages in doing 10K in 42 minutes instead of, say, 60 are bragging rights and getting finished & to the shower/pub/other faster afterwards!
Also note that those studies (well, the ones I've seen) compared like for like too (same pace over the distance, studying flat(ish) road racing or treadmill running. I find 16-to-20K trail running with a group (sometimes more of a "fast trek" than a run depending on terrain!) to work out much better for me than 10K road running at full pace.