How likely is it that a successful model involves _sizable_ losses?
Venture captialists' strategy involves mostly taking sizable losses, but with enough breakout successes to still make money in the aggregate.
They've got some pretty good arguments in favor of this, too: https://vanguardblog.com/2016/10/13/when-nothing-is-somethin...
They do a great job with VTI and their other funds to attempt to minimize the requirement of actually selling assets when liquidation requests come in, but that's not the same as saying that they, Vanguard (and more accurately the fund managers), practice a "Buy and Hold" strategy. Tracking an index well actually requires lots of buying and selling!