String indexing is pretty rare. Most of them are s[0] or s[:n], where you don't need an index.

Typically this is found when parsing something, eg.

    if line[0] == '#':
      # skip comment lines
      continue

Or

    prefixes = {...}
    for line in lines:
        prefix, remainder = line[:4], line[4:]
        if prefix not in prefixes:
            raise ValueError('Invalid prefix ' + prefix)
        parsed = prefixes[prefix](remainder)