What’s really causing the prescription drug crisis?
latimes.com
latimes.com
A recent article suggested that Purdue Pharmaceuticals dosing guidelines pretty much guaranteed addiction to OxyContin, by advising doctors to only ever prescribe the drug at 12 hour intervals despite the fact that it wore off more quickly for a large number of patients.
When patients complained about the drug wearing off early, Doctors were advised to not adjust the schedule but instead increase the dosage.
The pain-pleasure-reward cycle when the drug wears off early is what creates the physical addiction, and increasing the dosage only made it worse.
Purdue insisted on a 12 hour schedule because that is the marketing differentiater between OxyContin and generic opiates.
"The researchers found that doctors in a state where marijuana is legal ended up prescribing an average of 1,826 fewer doses of painkillers per year"
That's not to say marijuana cannot be abused nor is it a silver bullet, but in the middle of an opioid epidemic, holy shit, maybe something many people are illegally using to manage chronic pain without causing an epidemic; maybe it might be worth studying? The vast majority of users continue to be productive members of society; judging by the number of states that have legalized marijuana, we should be in the middle of a marijuana crisis compared to opioids, yet no such crisis exists. Yet the DEA classifies marijuana as having zero medical benefit, which makes it almost impossible, practically speaking, to study properly.
By the way, props to your nick :)
Quite what results in a given area having a given addiction of choice I'm not sure, but it can definitely vary over time - some parts of britain had a generational thing where the older addicts were all alcoholics and the younger ones were all on heroin, but my father (who worked in probation) said that among his clients other than the choice of substance affecting what sort of physical damage they suffered the rest of the issues were basically identical.
My point is that the doctors and the health system are responsible and should not take any drug company instructions as gospel.
It's puzzling to me how drug regulation persists in the face of examples like we have. The argument goes "oh, we need gatekeepers to protect citizen safety." But then these gatekeepers proceed to prohibit marijuana as a dangerous substance unsafe for any use, which is absurd, before turning around to recklessly prescribe oxycontin. How is the current prescribing monopoly / regulation regime really keeping people safe? To me, it's only resulted in lack of competition in health care provision, a militaristic police force, a lack of hemp, and an epidemic of narcotic addiction that benefits doctors and hospitals. A physician-police-industrial complex.
If anything, it increases the dangers, because it creates the illusion of safety and shifts responsibility onto a concentrated authority, who has their own agenda and interests that do not necessarily align with the long-term best interests of the citizen in need.
Someone involved in this is getting shot into the Sun, right?
I think this is just because they are being prescribed more frequently. Unhappy people with no opiate experience aren't just going out on the street and buying heroin, but unhappy people who are prescribed opiates may become addicted. The argument the article is making is that happy people who are prescribed opiates don't become addicted, and that it makes more sense to treat the unhappiness than to restrict opiate prescriptions.
I'm not saying its great on the liver, but under normal dosage and (provided you dont have liver disease) its safe. about as safe as having a few beers at the bar at least.
Another couldn't deal with her marriage falling apart. Prison also didn't help her learn how to better deal with life.
I believe the third was turned into an alcoholic by methadone. The etiology of this one's addictions is fascinating, but I think the main consideration is the lack of stability growing up. Money was never a problem, but her family life during childhood and teenage years was ... sub-optimal.
Emotionally-stable people tend to not become addicted to alcohol, heroin, cocaine, etc. I've met former cocaine users whose attitude is "been there, done that, no need to use again." That's kind of my attitude about alcohol - I don't care for it at all, no matter the price.
A wise woman once said, "... When a person feels safe, the false ego goes away." Helping people feel safe should be the #1 priority of every effort to help someone with substance abuse problems.
https://www.ncbi.nlm.nih.gov/pubmed/2616610?dopt=Abstract https://www.ncbi.nlm.nih.gov/pubmed/9148292?dopt=Abstract
Exactly this thought. I've helped a lot of kids over the year through abusive homes and the greatest thing you can give them is the feeling of safety above all else. This isn't necessarily helicopter parenting, but it's attentive to the needs to help them feel like they can fail without losing the essential securities of life.
Of the three alcoholics I mentioned, only one was (possibly/probably) triggered by methadone maintenance therapy.
Methadone is well-known to cause sugar cravings. This one started drinking heavily after about a month of methadone. She justified this as 'okay' because she wasn't driving.
Alcohol is just another form of fuel (derived from carbohydrates) for the body to burn. The alcoholic brain preferentially burns acetate (one of the breakdown products of ethanol):
https://www.jci.org/articles/view/65153 https://www.medicaldaily.com/heavy-drinking-alcohol-actually...
Apparently an old strategy for dealing with alcohol cravings is to feed them tons of sugar.
Gin isn't legal the way it was back then. It's only sold in stores and places with liquor licenses, it's heavily taxed, and there are all sorts of rules surrounding it. If in we had gin carts every twenty feet hawking it at kids and the homeless and it only cost a few cents per shot, I'm sure we'd have all the same problems.
EDIT: forgot: it's very cheap. If I remember correctly, you can get a one litre bottle for < 10 EUR - certainly not the best there is but "good enough" to get drunk as f* - even with little or no money
A liter of Smirnoff is $17.
People did tend to look a little like Hogarths Gin Street on Saturday and Sunday mornings.
I'm not saying those laws shouldn't exist, but they serve as a source of revenue, not as something that protects the public.
How is anything you stated remotely analogous to what is in the article.
Why not weed or alcohol? Because opiates produce a high and make you feel good. Much like work might, if you had it.
I think the second big problem after feeling safe is identity. A lot of people see their work as there identity.
This is not going to play out well with automation and the removal of jobs.
As for why opiates? They produce a much cleaner high probably.
Compare this to where we were 2,000 years ago or 10,000 years ago.
But this doesn’t occur. The Canadian physician Gabor Maté argues in his book “In the Realm of Hungry Ghosts” that studies examining the medicinal use of narcotics for pain relief find no significant risk of addiction. I’ve talked with doctors in Canada and Europe about this very issue. They say it’s vanishingly rare for a patient given diamorphine or a comparably strong painkiller in a hospital setting to develop an addiction.
OTOH oxycodone is almost always orally administered which means patients stay on it for longer in hospital and are commonly discharged with a prescription for more.
The doctors I work with who have done fellowships in USA state that oxycodone is (?was) given out like lollywater compared to hospitals here, where it is only prescribed if the patient has a REALLY good reason they can't have oral morphine.
Drug wholesalers shipped 780 million prescription painkillers to West Virginia over a six-year period. In a state of 1.84 million residents, the shipments amount to 433 pain pills for every man, woman and child in West Virginia.
http://www.nbcwashington.com/news/local/Drug-Wholesalers-Shi...
>The doctors I work with who have done fellowships in USA state that oxycodone is (?was) given out like lollywater compared to hospitals here, where it is only prescribed if the patient has a REALLY good reason they can't have oral morphine.
My experience as a medical student on elective in the US was this - I couldn't believe the quantities of opiates prescribed cf. Australia
For long term pain opioids don't treat the pain, and they risk addiction.
That's why we have things like "Opioids Aware": http://www.fpm.ac.uk/faculty-of-pain-medicine/opioids-aware
I imagine if you or someone very close to you had severe chronic pain your ill informed opinion would soon change.
You end taking life threateningly high doses of opioids, which are not working to reduce your pain.
People with chronic pain need other interventions - rapid access to specialist pain clinics being most important.
That's not so black and white. They work to some extent as long as dosages don't keep escalating and use is intermittent. Even the link you posted says as much.
I don't understand why "give people with chronic pain rapid access to specialist pain management clinics, rather than just dumping them on ever increasing opioids" is a controversial statement.
does that happen with people taking them? i felt when I took oxycodone I wanted to be left alone. it could have also been I was physically unwell, but it felt like the 'wanting to be alone' was a symptom and wasnt in pain
What opiates do is they simply make you feel good. They give you a feeling of enjoying yourself. They don't make you ecstatic (for most people), but they give you all the pleasant feelings you could get after - for example - running and winning a race, for free. How those feelings affect your actions differs from person to person.
The interesting question is how you could show rigorously that this type of safety net is effective.
also out of curiosity, did you read the article?
Some people use and abuse drugs, drink, gamble, who cares? It's a victimless crime.
By definition a victimless crime involves consenting parties with no harm to outside parties. There can be situations where something does impact a non-consenting party, which is when it stops being victimless.
I think it involves no victims, including the consenting parties.
Suicide is not a victimless crime (assuming it's a crime)
Attempted suicide would be a victimless crime.