Seattle median home value is $612,000. San Francisco median home value is $1,132,300 (zillow).

Assuming all other factors are equal that means you need to save almost twice as much for a down payment in these areas. If you are making >100k/year CA income tax will further complicate matters.

Seattle home prices are about 1/2 SF. There is no state income tax, so add on 8% to your income. Salaries are slightly lower, but not by much.

If you don't care about culture and just want to make/save lots of money, this is the place to be.