ps: refresh done, still lagging on tab open/close. That said, I use Nightly, and I'm not sure it's not instrumented and thus slower..
I do not think that Nightly should be any slower than say Dev Edition (Aurora) or the stable release. What's your default page when opening a new tab? Maybe it's because your start page needs long to load?! Mine is "about:home" (set with https://addons.mozilla.org/en-US/firefox/addon/new-tab-overr...)
If you have LastPass, make sure you updated to plugin 4.x. Earlier versions didn't play nicely with the new multithreading, causing big lags.