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Fructose actually has a very low glycemic index, about 20 compared to 100 for glucose and about 68 for sucrose. HFCS has a glycemic index of about 62.

If you want to follow a low glycemic index diet, it's much more important to avoid potatoes, white bread, white flour and rice than HFCS

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While it's nice that fructose doesn't raise blood sugar like the other monosaccharides, you need to keep in mind that fructose gets preferential uptake treatment by the liver. If you eat too much of a food that contains fructose, you can overwhelm your liver into producing triglycerides (see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC302539). While we're not entirely sure that triglycerides themselves are responsible for ill health, having elevated levels has been linked to all sorts of chronic diseases.

An issue that is just as great as that ^ is that fructose is a glycating agent potentially reaching high concentrations is the liver, causing direct damage to it, elevating liver enzymes and contributing to non-alcoholic fatty liver syndrome.

http://wholehealthsource.blogspot.com/search/label/liver

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