The biggest thing is are the Android apps actually usable...

I bought a Pixel C and it was a horrible experience using mostly all apps... most major apps only support landscape, there is no auto focus on text boxes, horrible graphics in full screen, etc... I returned it 1 hour after using it.

You can install Remix OS and their way of dealing with this is scaling down apps to mimic a phone interface. I'm not sure how Chrome OS will solve this problem.

There's virtually no Android apps made for these interfaces/sizes.