Yes, I've been meaning to replay the whole Mass Effect series as a Renegade character, but I can't get myself to actually do it.
In the first game it does usually mean being an asshole for no reason, so that one's hard to play other than nearly-pure paragon. Except for hanging up on the council every time you talk to them—they give you plenty of reasons, and you should definitely always do that.
[EDIT] typo fix
And the Council, yes - they worked hard to make me regret saving them in ME1...
Except in WWII games. During the early days of WWIIonline there were a few people who took playing german units a little too seriously and were quietly asked, told, to stop. I was a member of a german squad that rarely participated in mass offensives specifically to avoid confrontations with die-hard "recreationists".
(Fyi, WWIIOL was probably the first mmorpg in a persistant game space. This was new territory.)
Then there's open world games like Fallout that allow you to steal everything not nailed down in entire settlements, gaining more currency and supplies than you can likely ever use. It feels cheap to me and I find it more interesting and challenging to obtain what I need more ethically.
I usually end up being some form of neutral character.
So yes, the bully scammers exist, but I think that compared to any other MMO, a greater percentage of the community actually cares about others.
Doesn't change the fact that they will blow your ship up given half a chance though :P
With things like Skyrim or Deus Ex, the NPCs seem like lifeless robots (shoot them in the foot and they die, for example) and I feel nothing as I turn cities into mountains of skulls and rivers of blood.