I've been working 100% remote for 5 of the past 10 years, and part-time remote the other 5, and in none of this time have I gone stir-crazy or felt depressed about my work... some people are able to thrive in a remote/isolated environment (I still do video calls 2-4x a day for different projects, so it's not like total isolation), while others really need a group of people working with/around them to thrive.
It also helps to have a family or more than one other person living in your residence if you choose to remote work from home—it forces you to have face-to-face human interaction (to the extent you choose to put down smartphones, laptops, etc. outside of work hours).