I'm not sure about that... a large part of subsidies is to compete in foreign markets. A
LOT of food is produced in the U.S. and the majority of trade is so we can get the likes of strawberries year round. A lot of the food staples like grains, beans, nuts, cereals, etc are domestic. Even a lot of the soy and corn. That doesn't mention that we do supply our own meat the vast majority of the time.
I think what would harm us more in total isolation would be the lack of more scarce resources (those used in electronics, batteries etc). We have a lot of materials here, but there are others where China and Africa trade are needed.