like, say, New York City? Sure!
No, the rooftop garden on the Park Slope Whole Foods does not count.
While its highly unlikely, its slightly more believable that in the event of another world war or some kind of global food epidemic, a country that doesn't produce its own food might be completely screwed.
Trade is necessary for the wealth of modern economies. Self-sufficiency is North Korea's approach.
https://www.ers.usda.gov/topics/international-markets-trade/...
Net imports is a different question.
My expectation is that it would far more expensive, raising food prices and doing significant harm to the economy. Also imagine the massive costs of shifting production and the gap in food availability during the shift. But I agree that the U.S. wouldn't starve.
I think what would harm us more in total isolation would be the lack of more scarce resources (those used in electronics, batteries etc). We have a lot of materials here, but there are others where China and Africa trade are needed.